San Francisco 49ers running back Christian McCaffrey has been placed on injured reserve due to Achilles and calf injuries. He will miss at least the next four games, with a potential return on October 10 against Seattle. Jordan Mason is expected to take over lead running-back duties in McCaffrey's absence.
- McCaffrey's injury is significant, impacting the 49ers' offense.
- Jordan Mason will be the primary running back while McCaffrey is sidelined.