San Francisco 49ers cornerback Charvarius Ward has been declared inactive for the game against the Seattle Seahawks due to a knee injury. This unexpected absence comes after he participated in limited practices leading up to the game. The 49ers will now face the Seahawks without their top cornerback, which could significantly impact the performance of Seattle's wide receivers, DK Metcalf and Tyler Lockett.

• Charvarius Ward's absence is a significant blow to the 49ers' defense.
• The Seahawks' passing game could thrive without Ward covering Metcalf and Lockett.