The Seattle Seahawks will face the San Francisco 49ers without their top edge defender, Uchenna Nwosu, who is sidelined due to a thigh injury. Nwosu had just returned from an MCL sprain but was unable to finish his season debut. Additionally, rookie defensive tackle Byron Murphy II is also expected to miss the game due to a hamstring injury. The Seahawks are struggling with injuries, which could impact their performance as they aim to break a five-game losing streak against the 49ers.

• The Seahawks will be without key defensive players in their upcoming game against the 49ers.
• Uchenna Nwosu's absence is significant as he is considered the best edge defender on the team.
• The Seahawks have struggled against the 49ers historically, losing five straight games.