The San Francisco 49ers have placed running back Christian McCaffrey on injured reserve following a PCL sprain in his right knee. This injury occurred during a recent game against the Buffalo Bills, and McCaffrey is expected to miss the remainder of the regular season. Head coach Kyle Shanahan indicated that McCaffrey will need approximately six weeks to recover, potentially allowing for a return only if the 49ers make an unexpected playoff run. McCaffrey's season has been plagued by injuries, limiting him to just four games in 2024.