San Francisco 49ers quarterback Brock Purdy has been ruled out for the upcoming game against the Green Bay Packers due to shoulder soreness. Despite initial optimism about his condition, Purdy's situation has worsened, leading to his absence. The team is hopeful for his return in Week 13 against the Buffalo Bills, but his availability will depend on his progress in practice leading up to that game.

• Brock Purdy's shoulder injury has led to his absence in Week 12.
• The 49ers are cautiously optimistic about his return in Week 13, but it's not guaranteed.