San Francisco 49ers running back Isaac Guerendo will miss the upcoming game against the Miami Dolphins due to a foot and hamstring injury. This leaves the 49ers with a limited backfield, featuring Patrick Taylor, Ke'Shawn Vaughn, and Israel Abanikanda. The situation is complicated by a tough matchup against a Dolphins defense that has been strong against opposing running backs recently.
- Isaac Guerendo's absence creates uncertainty in the 49ers backfield.
- Patrick Taylor is expected to lead the backfield, but the exact distribution of carries is unclear.
- The Dolphins' defense has been effective against running backs, limiting them to 2.8 yards per carry over the last five weeks.
Patrick Taylor | RB

Pickup
- Expected to take on a larger role in Guerendo's absence.
- Uncertainty remains on how the backfield will be utilized.
Ke'Shawn Vaughn | RB

- Part of the backfield rotation but less favored than Taylor.
Israel Abanikanda | RB

- Also in the mix for carries but not expected to lead.
San Francisco 49ers

- Dealing with injuries in the backfield heading into a tough matchup.
Miami Dolphins

- Strong defensive performance against running backs in recent weeks.