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The San Francisco 49ers will be without their top two running backs, Christian McCaffrey and Jordan Mason, as both are headed to injured reserve. McCaffrey is dealing with a PCL injury in his right knee, which is expected to require a six-week recovery period, while Mason has a high ankle sprain. Rookie Isaac Guerendo will take over as the starting running back for the 49ers, who are struggling at 5-7 after a recent loss to the Buffalo Bills.
- The 49ers' running back situation is dire with both McCaffrey and Mason out.
- Isaac Guerendo will be the starting RB moving forward.
Christian McCaffrey | RB
Injury
Week 12
7 carries
53 rush yards
- Placed on IR due to a PCL injury in his right knee.
- Expected to miss six weeks but will not require surgery.
- Had 53 rushing yards on 7 carries in his last game before injury.
Jordan Mason | RB
Injury
Week 12
13 carries
78 rush yards
- Also headed to IR with a high ankle sprain.
- Led the team in rushing this season with 789 yards and 3 touchdowns.
Isaac Guerendo | RB
Pickup
Week 12
- Will assume starting duties following injuries to McCaffrey and Mason.
- Scored the lone touchdown for the 49ers in the last game.
San Francisco 49ers
- Currently last in the NFC West with a 5-7 record.
- Struggling with injuries to key players, especially in the running back position.