Isaac Guerendo, a rookie running back for the San Francisco 49ers, is poised to make his first NFL start this Sunday against the Chicago Bears due to injuries to Christian McCaffrey and Jordan Mason. Coach Kyle Shanahan believes Guerendo is ready to step up after showing improvement throughout the season. With a solid performance in limited opportunities, Guerendo has the chance to establish himself as a key player for the 49ers in the final weeks of the season.

• Isaac Guerendo will start due to injuries to McCaffrey and Mason.
• Guerendo has shown promise with a 5.9 yards per carry average.
• The 49ers are looking for Guerendo to seize this opportunity and develop into a key player.