The San Francisco 49ers have placed star running back Christian McCaffrey on injured reserve due to a PCL injury in his knee, which will keep him out for at least six weeks. This injury occurred during the first half of a recent game against the Buffalo Bills, and with the 49ers struggling at 5-7, McCaffrey's return may not happen this season. His backup, Jordan Mason, has also been placed on IR, elevating Isaac Guerendo to the starting RB position.
- McCaffrey's injury is significant, impacting both his fantasy value and the 49ers' playoff hopes.
- Isaac Guerendo is now a priority add in fantasy leagues as he steps into the RB1 role.