Isaac Guerendo, running back for the San Francisco 49ers, is set to be limited in practice due to ongoing foot and hamstring injuries. After missing Week 16, he is making a return to practice, which could be beneficial for the 49ers as they face the Lions in Week 17 without key players Christian McCaffrey and Jordan Mason. His ability to participate in practice this week will be crucial for his availability in the upcoming game.

• Guerendo's return to practice is a positive sign for the 49ers' backfield.
• The 49ers are dealing with multiple injuries in their running back group.