Christian McCaffrey suffered a potential season-ending PCL injury during a game against the Bills. This injury comes after he had just returned from an Achilles tendinitis issue that caused him to miss eight games earlier in the season. With the 49ers struggling at 5-7, they may have to rely on backup running backs to fill the void left by McCaffrey as they aim for a playoff spot.
- McCaffrey's injury could significantly impact the 49ers' playoff hopes.
- Backup running backs Jordan Mason and Isaac Guerendo may see increased roles.