San Francisco 49ers wide receiver Brandon Aiyuk did not participate in Wednesday's practice, causing some concern as the team prepares for Week 1. While the 49ers had been supportive of Aiyuk's hold-in during training camp, they are eager to have him back on the field. His absence could impact the team's offensive strategy as they head into the season.

• Brandon Aiyuk's absence could affect the 49ers' offensive plans for Week 1.
• The team has shown understanding towards Aiyuk's situation but needs him back on the field.