The San Francisco 49ers will be without left tackle Trent Williams for the fourth consecutive game, while defensive end Nick Bosa and linebacker Dre Greenlaw have a chance to return. Williams, along with safety Malik Mustapha and guard Ben Bartch, has been ruled out for the upcoming game against the Los Angeles Rams. Bosa has missed three games due to injury but participated in practice, while Greenlaw is looking to make his season debut after recovering from an Achilles injury sustained in the Super Bowl. Running back Isaac Guerendo is also questionable but has shown progress in practice.

• Trent Williams continues to be a significant loss for the 49ers' offensive line.
• Bosa's potential return could bolster the defense significantly.
• Greenlaw's activation would be a major boost after missing the entire season so far.