After the 49ers' loss to the Bills, head coach Kyle Shanahan announced that running back Christian McCaffrey is dealing with a PCL injury that may be season-ending. McCaffrey is set to undergo further testing to assess the extent of the injury. In his potential absence, Jordan Mason is expected to take over as the lead running back, having significantly outperformed his teammate in carries during the game against Buffalo.
- Christian McCaffrey's injury could be a major blow to the 49ers' offense.
- Jordan Mason emerges as a key waiver wire target for fantasy players.