In the season opener against the Cardinals, James Cook showcased his skills as the lead running back for the Buffalo Bills, accumulating 103 total yards. Despite a solid performance, Cook's potential for touchdowns may be limited due to the presence of quarterback Josh Allen and the recent addition of rookie Ray Davis, who may take away goal-line opportunities.
- James Cook is the clear lead back for the Bills but may face competition for goal-line carries.
- Josh Allen continues to be a significant factor in the Bills' rushing touchdowns.