The Buffalo Bills have activated linebacker Matt Milano off injured reserve, allowing him to potentially play in their upcoming game against the San Francisco 49ers. Milano, who has been sidelined since suffering a leg injury in October 2023, is expected to enhance the Bills' defense significantly. His return comes as the team aims to clinch the AFC East with a win this week. Meanwhile, rookie defensive tackle DeWayne Carter has been downgraded to out for the game, and other roster adjustments have been made.

• Matt Milano's return is a significant boost for the Bills' defense.
• The Bills are in a strong position to clinch the AFC East with a win.