San Francisco 49ers running back Isaac Guerendo has been diagnosed with a foot sprain and is considered day-to-day ahead of Thursday's game against the Rams. Guerendo had a standout performance in the previous game, accumulating 128 scrimmage yards and two touchdowns before exiting due to injury. With key players on IR, Guerendo was expected to be the starting running back moving forward.
- Guerendo's injury status is critical for the 49ers' backfield depth.
- With multiple running backs on IR, Guerendo was poised for a larger role.