San Francisco 49ers wide receiver Deebo Samuel is not practicing due to a calf injury, raising concerns about his availability for upcoming games. Samuel had been contributing significantly in both rushing and receiving roles, especially with Christian McCaffrey sidelined. The 49ers may face challenges in their offensive lineup with multiple key players injured, including George Kittle.

• Samuel's calf injury could lead to a multi-game absence.
• With McCaffrey out, Samuel had been utilized more in the backfield.
• The 49ers are facing significant injury issues among their top skill-position players.