Clyde Edwards-Helaire has been ruled inactive for the Kansas City Chiefs' game against the San Francisco 49ers due to an illness. Despite being off the final injury report, the Chiefs have decided to utilize other running backs in his absence, including Kareem Hunt, Carson Steele, and Samaje Perine.

• Clyde Edwards-Helaire's absence opens up opportunities for other running backs on the Chiefs roster.
• The Chiefs are opting for a committee approach with their running backs against the 49ers.