Isaac Guerendo, running back for the San Francisco 49ers, has been dealing with foot and hamstring injuries. After missing Week 16's game against the Dolphins, he returned to practice in a limited capacity ahead of Week 17. His status for the upcoming game against the Lions remains uncertain, but if cleared, he is expected to reclaim his role as the lead runner for the 49ers.

• Guerendo has been limited in practice but is making progress.
• His potential return could impact the 49ers' running game significantly.