Eric Dickerson holds the record for the most rushing yards in a single NFL season, with an impressive 2,105 yards achieved in 1984 while playing for the Los Angeles Rams. As the NFL has transitioned to a 17-game regular season, the record may be more attainable for current players. The article also lists the top rushing yard leaders in NFL history, highlighting the proximity of several players to Dickerson's record.

• Eric Dickerson's 2,105 rushing yards in 1984 remains the single-season record.
• The shift to a 17-game schedule may allow current players to challenge this record.