The San Francisco 49ers are set to be underdogs for the first time since 2022, ending a streak of 36 consecutive games as favorites. Currently, the Green Bay Packers are three-point favorites against the 49ers, influenced by injury concerns surrounding key players including QB Brock Purdy, OT Trent Williams, and DE Nick Bosa. This season, the 49ers have struggled with a 5-5 record, marking a significant shift in their performance compared to previous seasons.
- The 49ers' underdog status highlights their recent struggles this season.
- Injury concerns for key players have impacted betting lines significantly.