Aiyuk finished with a modest fantasy line as quarterback Brock Purdy spread the ball around to all of his star playmakers in the blowout victory.
Aiyuk's 58 receiving yards wound up being the game high for wideouts from either team Sunday.
The fourth-year receiver is now averaging 97.5 yards over four active games this season after gaining 59.7 per game during his breakout campaign last year.