The San Francisco 49ers have placed wide receiver Brandon Aiyuk on injured reserve after he suffered significant knee injuries during a recent game against the Kansas City Chiefs. Aiyuk's injuries, which include tears to both the ACL and MCL, will require a lengthy rehabilitation process, leaving the 49ers with limited options at the wide receiver position for the remainder of the season.

• Brandon Aiyuk is likely done for the season due to ACL and MCL tears.
• The 49ers will rely on Deebo Samuel and Jauan Jennings, but their availability is uncertain.
• Rookies and second-year players may see increased playing time in Aiyuk's absence.