The San Francisco 49ers are set to be underdogs for the first time since 2022, ending a remarkable streak of 36 consecutive games as favorites. The Green Bay Packers are currently favored by three points over the 49ers, marking a significant shift in betting odds influenced by key injuries to 49ers players. This season, the 49ers have struggled with a 5-5 record, raising concerns about their ability to compete effectively.

• The 49ers are underdogs for the first time since 2022, breaking a long streak.
• Key injuries to Brock Purdy, Trent Williams, and Nick Bosa are impacting the team's performance and betting odds.
• The 49ers have a disappointing 5-5 record this season.