San Francisco 49ers running back Christian McCaffrey has been ruled out for the season opener against the New York Jets due to a calf injury, despite earlier optimism from both the player and coaching staff. McCaffrey has been dealing with calf and Achilles issues since early training camp and was expected to return in time for the game. With McCaffrey sidelined, Jordan Mason is set to make his first career start at running back.
- Christian McCaffrey's injury status was uncertain leading up to the game, but ultimately he was ruled out.
- Jordan Mason will start in McCaffrey's absence, marking a significant opportunity for the young running back.