San Francisco 49ers running back Christian McCaffrey was ruled out of the game against the Buffalo Bills due to a right knee injury sustained in the second quarter. McCaffrey had shown promise early in the game, recording 53 rushing yards and 14 receiving yards before the injury forced him to leave. An MRI is scheduled for Monday to assess the extent of the injury. This marks a setback for McCaffrey, who was gradually returning to form after a lengthy absence due to Achilles tendinitis.
- McCaffrey's injury is a significant concern for the 49ers as he was just starting to regain his form.
- The team will await MRI results to determine the severity of the injury.